With only eight teams remaining and with no other big clubs in sight, Manchester United are heavily favored to lift the Europa League.
But they must still go through with the knockout stages, starting with their visit to Stade Constant Vanden Stock in the first leg of their quarter-final tie with Belgian club Anderlecht.
United had a hard time shaking off Russian side Rostov in the last round, only advancing after a tight 1-0 win at home following a 1-1 draw in Russia.
Manager Jose Mourinho has already said he will prioritize to win Europa League, and will refrain from using his players in domestic competitions so they are rested for the intercontinental one.
Next to United in the betting for outright Europa League winners are Lyon, the French club who outlasted Italian giants Roma 5-4 in a thrilling two-legged Last 16 tie. In the last eight, Lyon face Besiktas, who advanced after dominating Greek club Olympiakos 5-2.
La Liga’s Celta de Vigo cruised past Krasnodar 4-1 in the Last 16 and will be up against Genk, who outclassed another Belgian side Gent.
Ajax, who eked a 3-2 aggregate victory over Copenhagen in the last stage, will try to advance as they face Schalke 04, who eliminated their Bundesliga rivals Borussia Monchengladbach via away goals rule.